What is the evidence for the efficacy of treatments for idiopathic hypersomnia and their proposed mechanism of action?

Introduction: Idiopathic hypersomnia (IH) is a poorly understood neurological disorder that was only recently described in 1976 by Roth et al (1). The symptoms of excessive daytime sleepiness, prolonged nocturnal sleep or daytime naps, difficulty waking with cognitive impairment can frequently overlap with symptoms of other causes of hypersomnia such as sleep deprivation, narcolepsy type […]

Is there evidence that circadian rhythm disruption has a role in psychiatric disorders?

Introduction The link between sleep and psychiatric disorders has been long observed. In the 1980s, Wehr et al published his findings of circadian rhythm disturbances in manic-depressive illness (1). In the 1970s, Wirz-Justice at al reported the association of sleep deprivation in endogenous depression (2). Almost all psychiatric illnesses have circadian abnormalities with respect to […]